A diet based on unrefined plant foods high in fiber, phytochemicals, vitamins and minerals as naturally occurring in food was compared to a typical low-fiber and low-phytochemical, non-plant-based diet in healthy human subjects. Key foods in the "whole food" diet were sun-dried raisins and whole grain raisin bread (for a total amount of 4 1/2 ounces of raisins a day), rounded out by other whole grain products, plenty of fruits and vegetables, beans and lentils, nuts and oil seeds like sesame. Green and ginger tea—both high in phenolic antioxidants—were chosen as the key beverages. Meat and animal products were kept to a minimum to make this a true "plant-based diet."

The subjects were first placed on a typical Western diet high in refined food that included white flour products and no whole grains, no dried fruits or nuts, limited fresh fruits and vegetables, more and free consumption of meat and other animal products for four weeks. Their total cholesterol, “good” cholesterol and “bad” cholesterol and selected antioxidant blood enzymes were measured at the end of that period. Subjects were then switched for four weeks to the unrefined whole food diet: their total and “bad” cholesterol and triglycerides were reduced, and no significant change occurred in their “good” cholesterol. And the body appeared to need less antioxidant defense as measured by the blood levels of the antioxidant blood enzymes that were measured. As expected on higher fiber diets, colon function become more regular and fecal elimination easier.

From these findings it can be concluded that a diet abundant in phytochemically-rich foods, such a sun-dried raisins and other whole and unrefined foods, can beneficially affect blood cholesterol, improve colon function, and decrease the need for antioxidant defenses.

Bruce, B, Spiller GA, Klevay LM, and Gallagher, SD. A diet high in whole and unrefined foods favorably alters lipids, antioxidant defenses, and colon function. J. Am Coll Nutr 19(1): 61-67, 2000